Helping patients save
on KRAS G12C testing

1 in 8 people living with non-small cell lung cancer (NSCLC*) have the KRAS G12C gene mutation.1 Testing for biomarkers like KRAS G12C is important because it can help your doctor tailor your treatment plan.2

Biomarker Assist can help you save on the cost for KRAS G12C testing. Program limitations apply, please see terms and conditions including limits on individual program coverages.

*Based on non-squamous patient population.

About KRAS G12C in non-small lung cancer (NSCLC)

What is NSCLC?

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for about 80%-85% of lung cancer cases.3 Your doctor may talk to you about the type and stage of your disease, using numbers that show the level of severity and if it has spread. For example, stage 0 lung cancer is less severe and localized, and stage IV is more severe and has spread. There can be different treatments for lung cancer depending on the type and stage, so knowing the stage can help guide your doctor’s treatment choices.4

What are biomarkers in cancer?

A biomarker is a code in your tumor that contains important information which can help your doctor understand what’s causing your tumor to grow and spread. KRAS G12C is a type of biomarker in NSCLC.5

What is KRAS G12C biomarker?

KRAS is a protein we all have in our bodies that works like an on/off switch, telling our cells when to grow and when to stop growing. Sometimes this protein can mutate (change). KRAS G12C is one of these mutations, and it makes the on/off switch get stuck in the “on” position. This causes cells to multiply uncontrollably and grow into tumors.6-8

How and why test for KRAS G12C?

Laboratories can analyze a tissue sample of your tumor (from a biopsy) or in some cases your blood to test for any biomarkers it may have. Biomarkers can provide information about your type of cancer. There are two kinds of biomarker tests that your doctor can order. Next Generation Sequencing is a test that looks for many different kinds of biomarkers at a time. Single Gene Testing is used by doctors to look for just one biomarker at a time.9 Getting tested will show if you’re among the 1 in 8 people with NSCLC who have the KRAS G12C biomarker.1 With this information in hand, your doctor can tailor your treatment plan.2 Ask your doctor which test may be right for you.

Biomarker Assist Testing Programs

After your doctor decides which test is right for you, two different programs can reduce the cost of testing. Read more about these programs below:

  • Next Generation Sequencing (NGS) Affordability Program
  • KRAS Single Gene Test (SGT) Program

Biomarker Assist:

NGS Affordability Program

If your doctor chooses NGS, the program will help with your payment if you meet certain criteria.

  • Must be diagnosed with stage IV (advanced or metastatic) NSCLC
  • NGS test must include the KRAS gene
  • Must have private commercial health insurance with NGS coverage (this program covers eligible patient's out-of-pocket obligations after insurance coverage)
  • Program does not cover any other costs, including, but not limited to, office visit fees and biopsy fees
  • One-time benefit: maximum benefit is $1000

See NGS Affordability enrollment form for full eligibility details; other restrictions may apply. Terms and Conditions

After your test is performed, you simply need to enroll

1. Complete Test
  • Your doctor will order a liquid or tissue biopsy from a lab
  • The lab will complete the test and then bill your insurance
2. Enroll Online

Have you received
your EOB?

Click here
to enroll

  • Gather required documents:
    • Explanation of Benefits (EOB)
    • Receipt from the lab or proof of payment
3. Reimbursement
  • You can expect to receive reimbursement within 7 business days after the documentation is received and approved
  • Alternatively, if the out-of-pocket has not yet been paid, the lab that completed the test can receive payment directly

If you do not wish to complete the form online, you may download, complete, and send the form and required documents to Biomarker Assist:

mail

Click here to download the enrollment form

fax

Submit by mail

Biomarker Assist
NGS Affordability Program
PO Box 2355
Morristown, NJ 07962

fax

Or submit by fax

1-866-671-9373

Biomarker Assist:

KRAS Single Gene Test Program

If your doctor chooses a Single Gene Test (SGT), there is nothing you need to do. If you are eligible to participate in the program, the doctor’s office will take care of the paperwork, and the cost of the test is covered through the program. Ask your doctor for more information about the process.

This is a summary; please see full terms and conditions for program requirements and limitations.

Program limitations apply, please see terms and conditions including limits on individual program coverages. Programs valid for testing performed through December 31, 2021.

Frequently Asked Questions

  • What is Biomarker Assist?

    Biomarker Assist is comprised of two programs, the Next Generation Sequencing (NGS) Affordability Program and the KRAS Single Gene Test (SGT) Program. Please refer to subsequent questions for more details on each program. Programs valid for testing performed through December 31, 2021.

  • What is the Biomarker Assist NGS Affordability Program?

    The Biomarker Assist NGS Affordability Program may help eligible, commercially insured patients lower out-of-pocket costs for their NGS biomarker test, including deductible, co-insurance, and co-payment. Eligible patients may pay as little as $0 out-of-pocket for their NGS biomarker test, up to the program maximum of $1000. There is no income requirement for the Biomarker Assist NGS Affordability Program.

    This is a summary; please see full terms and conditions for program requirements and limitations.

  • What is the Biomarker Assist KRAS Single Gene Test Program?

    The Biomarker Assist KRAS Single Gene Test Program is a voucher program to cover the costs of the KRAS Single Gene Test prescribed by your doctor. All you need to do is ask your doctor if this test is right for you.

    This is a summary; please see full terms and conditions for program requirements and limitations.

  • Who is eligible for Biomarker Assist?

    The Biomarker Assist NGS Affordability Program is available for eligible, commercially insured patients with stage IV (advanced or metastatic) non-small cell lung cancer (NSCLC) with NGS biomarker test coverage (this program covers eligible patient's out-of-pocket obligations after insurance coverage).

    The Biomarker Assist KRAS Single Gene Test Program is available for any patient with stage IV (advanced or metastatic) non-small cell lung cancer regardless of insurance type or status.

  • How does Biomarker Assist NGS Affordability Program reimbursement work?

    Eligible patients may pay as little as $0 out-of-pocket for the NGS biomarker test, up to the program maximum of $1000.

    • If you have paid your out-of-pocket responsibility to the lab, you will need to complete the enrollment, provide patient authorization, and send in your Explanation of Benefits (EOB) form with proof of payment to Biomarker Assist. An EOB is a statement from your health insurance plan describing what costs it will cover for medical care or products you’ve received. The EOB is generated when your provider submits a claim for the services you received. Biomarker Assist will review your enrollment EOB form and proof of payment to confirm eligibility. If eligible, a check will be processed and sent to your address.
    • If you have not paid your out-of-pocket responsibility to the lab, you will need to complete the enrollment, provide patient authorization, and send in your EOB form to Biomarker Assist. Biomarker Assist will review your enrollment and EOB form to confirm eligibility. If eligible, a check will be processed and sent to your lab.

    If you do not send the EOB form to Biomarker Assist within 180 days of the date of service, you will not be eligible for reimbursement. Test must be completed by December 31, 2021 and last day to submit documentation is June 29, 2022.

    If you paid your out-of-pocket to the lab, once the Explanation of Benefits (EOB) and proof of payment are received, and eligibility confirmed, the check if sent by UPS will arrive in 7 business days to the address you provided. If you have not paid your out-of-pocket to the lab, once the EOB are received, and eligibility confirmed, the check if sent by UPS will arrive in 7 business days to the lab.

    This is a summary; please see full terms and conditions for program requirements and limitations.

References: 1. Data on file, Amgen; [Analysis of AACR Genie v8]. 2. Gregg JP, et al. Transl Lung Cancer Res. 2019;8(3):286-301. 3. American Cancer Society. About Lung Cancer. Accessed January 31, 2021. https://www.cancer.org/cancer/lung-cancer/about/what-is.html 4. American Cancer Society. Treatment Choices for Non-Small Cell Lung Cancer, by Stage. http://www.cancer.org/cancer/lung-cancer/treating-non-small-cell/by-stage.html. Accessed March 19, 2021. 5. NCI, Biomarker Testing for Cancer Treatment. http://www.cancer.gov. Accessed March 2021. 6. NCI Dictionary of Cancer Terms, KRAS Gene. Accessed January 30, 2021. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/kras-gene 7. Ryan MB, Nat Rev Clin Oncol. 2018;15(11):709-720. doi: 10.1038/s41571-018-0105-0. 8. Hong DS, N Engl J Med. 2020; 383:1207-1217. doi:10.1056/NEJMoa1917239. 9. Sherwood JL, et al. ESMO Open. 2017;2:e00235.doi:10.1136/esmoopen-2017-000235.